Advancing Metabolic Health Through Clinical Research Studies

At Los Angeles Institute for Metabolic Research, we conduct clinical research studies focused on metabolic diseases that affect millions of people, including obesity, diabetes, metabolic (“fatty”) liver disease, and related conditions such as high blood pressure, high cholesterol, and sleep apnea.

Our research studies evaluate investigational therapies and new approaches designed to improve health outcomes. Participation is voluntary, and all studies are conducted under Institutional Review Board (IRB) oversight.

Whether you are newly diagnosed, living with a chronic condition, or simply interested in learning more, we invite you to explore our current clinical research opportunities.

Patrick Smith Patrick Smith

TRIUMPH-9 Study

This approximately 2-year study evaluates the investigational triple agonist retatrutide (GLP-1, GIP, and glucagon receptor agonist) in people with overweight or obesity.

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Synergy-Outcomes Study

The main purpose of the SYNERGY-OUTCOMES study is to find out whether retatrutide and tirzepatide (ZEPBOUND®) can prevent major adverse liver outcomes (MALO) in people with high-risk metabolic dysfunction-associated steatotic liver disease (MASLD), commonly known as “fatty liver disease.”

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CAPTAIN T2D Study

This study is exploring whether managing cortisol levels may help improve T2D. Cortisol is a hormone that can affect blood sugar and overall health when levels are too high. Many people with difficult-to-control T2D may not know if they have elevated cortisol.

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Patrick Smith Patrick Smith

ONWARDS 11 Study

This study is evaluating and investigational once-weekly basal (long-acting) insulin (insulin ICODEC) in combination with a rapid-acting (mealtime) insulin in people with T1D who are not achieving glucose targets using a multiple daily injection (MDI) insulin regimen.

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